Research FILE : Study Designs "vivo ⁄ vitro" in vivo YearName of Papers 2022 Effectiveness of a Fermented Functional Food on Telomere Dynamics and miRNAs in Middle-Aged/Elderly Healthy Individuals: A 2-Year Randomized, Double-Blind, Controlled Clinical Trial Entire bodyHealthy elderlyHealthy non-smokerin vivoClinical researchAnti aging 2020 MITOCHONDRIAL AND REDOX DYSFUNCTION IN POST-MENOPAUSE AS RISK FACTOR OF NEURODEGENERATIVE DISEASE: A PILOT STUDY TESTING THE ROLE OF A VALIDATED JAPANESE FUNCTIONAL FOOD Entire bodyin vivoClinical researchAnti aging 2020 Leaky Gut and Post-Prandial, Redox and Inflammatory Markers in HRT Treated Menopausal Females: Benefits by a Pharma-Grade Fermented Papaya Preparation (FPP-ORI) Entire bodyMenopausal Femalesin vivoClinical researchRedox balance 2020 Beneficial Effects of Fermented Papaya Preparation (FPP)Supplementation on Redox Balance and Aging in a Mouse Model Entire bodyMousein vivoBasic researchAnti aging 2019 Oral Administration of FPP Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response Entire bodyMousein vivoBasic researchCancer 2018 Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults - A Short Report of a Placebo-Controlled Clinical Trial BloodHealthy elderlyin vivoClinical researchHealthy individual 2018 Beneficial effects of a FPP for the treatment of electrohypersensitivity -self reporting patients : results of a phase I - II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis. Brainin vivoClinical research 2017 A 2-year Double-Blind RCT Follow-up Study with Fermented Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered Neurodegenerative Disease-Risk Factors Othersin vivoClinical research 2017 May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells? Systemic inflammatoryin vivoClinical research 2016 Effect of a quality-controlled fermented nutraceutical on skin aging markers: An antioxidant-control, double-blind study SkinHealthy non-smokerin vivoClinical research in vivo in vitro YearName of Papers 2015 The Effect of Fermented Papaya Preparation on Radioactive Exposure. Entire bodyHuman cellMousein vitroin vivoBasic researchRadiation Exposure 2015 The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity. Oral CavityHealthy individualHuman cellMicroorganismin vitroBasic researchOral diseases 2014 THE HIDDEN PHENOMENON OF OXIDATIVE STRESS DURING TREATMENT OF SUBCLINICAL-MILD HYPOTHYROIDISM: A PROTECTIVE NUTRACEUTICAL INTERVENTION Thyroid glandHyperthyroid female patientin vitroin vivoBasic researchClinical researchHealthy individual 2013 The inhibitory effect of a fermented papaya preparation on growth, hydrophobicity, and acid production of Streptococcus mutans, Streptococcus mitis, and Lactobacillus acidophilus: its implications in oral health improvement of diabetics Oral CavityMicroorganismin vitroBasic researchOral diseases 2012 The Antioxidant effect of Fermented Papaya Preparation (FPP) Involves Iron Chelation BloodHuman cellin vitroBasic researchIron overload disorder 2011 Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation BloodThalassaemia patientin vitroin vivoClinical researchβ- Thalassaemia 2008 Fermented Papaya Preparation as RedoxRegulator in Blood Cells of β-Thalassemic Mice and Patients BloodThalassaemia mouseThalassaemia patientin vitroin vivoBasic researchβ- Thalassaemia 2006 Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity NervesCellRatin vitroin vivoBasic research in vitro ex vivo YearName of Papers 2015 Does Oral Supplementation of a FPP Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients? Systemic inflammatoryType II Diabetes Mellitus Patientex vivoin vivoBasic researchType II Diabetes 2012 Correction of Aberrant NADPH Oxidase Activity in Blood-Derived Mononuclear Cells from Type II Diabetes Mellitus Patients by a Naturally Fermented Papaya Preparation. Systemic inflammatoryType II Diabetes Mellitus Patientex vivoClinical researchType II DiabetesWound healing ex vivo