We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.

Oral diseases

Year

Name of Papers

• 2015

  The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity.

  Oral CavityHealthy individualHuman cellMicroorganismin vitroBasic researchOral diseases

• 2013

  The inhibitory effect of a fermented papaya preparation on growth, hydrophobicity, and acid production of Streptococcus mutans, Streptococcus mitis, and Lactobacillus acidophilus: its implications in oral health improvement of diabetics

  Oral CavityMicroorganismin vitroBasic researchOral diseases

Oral diseases

Radiation Exposure

Year

Name of Papers

• 2015

  The Effect of Fermented Papaya Preparation on Radioactive Exposure.

  Entire bodyHuman cellMousein vitroin vivoBasic researchRadiation Exposure

Radiation Exposure

Cancer

Year

Name of Papers

• 2019

  Oral Administration of FPP Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

  Entire bodyMousein vivoBasic researchCancer

Cancer

Iron deficiency

Year

Name of Papers

• 2014

  IRON SUPPLEMENTATION IN YOUNG IRON-DEFICIENT FEMALES CAUSES GASTROINTESTINAL REDOX IMBALANCE: PROTECTIVE EFFECT OF A FERMENTED NUTRACEUTICAL.

  StomachNon-smoker (female)in vivoClinical researchHealthy individualIron deficiency

Iron deficiency

Iron overload disorder

Year

Name of Papers

• 2012

  The Antioxidant effect of Fermented Papaya Preparation (FPP)　Involves Iron Chelation

  BloodHuman cellin vitroBasic researchIron overload disorder

Iron overload disorder

Healthy individual

Year

Name of Papers

• 2018

  Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults　- A Short Report of a Placebo-Controlled Clinical Trial

  BloodHealthy elderlyin vivoClinical researchHealthy individual

• 2014

  IRON SUPPLEMENTATION IN YOUNG IRON-DEFICIENT FEMALES CAUSES GASTROINTESTINAL REDOX IMBALANCE: PROTECTIVE EFFECT OF A FERMENTED NUTRACEUTICAL.

  StomachNon-smoker (female)in vivoClinical researchHealthy individualIron deficiency

• 2014

  THE HIDDEN PHENOMENON OF OXIDATIVE STRESS DURING TREATMENT OF SUBCLINICAL-MILD HYPOTHYROIDISM: A PROTECTIVE NUTRACEUTICAL INTERVENTION

  Thyroid glandHyperthyroid female patientin vitroin vivoBasic researchClinical researchHealthy individual

• 2012

  Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects.

  Upper airwayHealthy individual without fitness habitsin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

• 2011

  REDOX BALANCE SIGNALLING IN OCCUPATIONAL STRESS: MODIFICATION BY NUTRACEUTICAL INTERVENTION

  NervesStressful personin vivoClinical researchHealthy individual

• 2010

  REGULATING REDOX BALANCE GENE EXPRESSION IN HEALTHY INDIVIDUALS BY NUTRACEUTICALS : A PILOT STUDY

  Entire bodyHealthy non-smokerHealthy smokerin vivoClinical researchHealthy individual

• 2007

  OXIDATIVE-INFLAMMATORY DAMAGE IN CIRRHOSIS. EFFECT OF VITAMIN E AND A FERMENTED PAPAYA PREPARATION

  LiverCirrhosis patientin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

• 2007

  Aston Martin Racing Le Mans 2007 Follow up of Oxidative Stress of 3 racers (DBR9N゜ 009) during 24 Hours race

  Entire bodyRacing driverin vivoClinical researchHealthy individual

• 2007

  Nutraceutical Strategy in Aging Targeting Heat Shock Protein and Inflammatory Profile through Understanding Interleukin-6 Polymorphism

  Entire bodyHealthy elderlyin vivoClinical researchHealthy individual

• 2006

  Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype

  Entire bodyHealthy elderlyin vivoClinical researchHealthy individual

Healthy individual

Middle-aged healthy individual

Year

Name of Papers

• 2012

  Cardioprotective Effect of a Biofermented Nutraceutical on Endothelial Function in Healthy Middle-Aged Subjects.

  Blood vesselMiddle-aged healthy individualin vivoClinical researchBlood vessel diseaseMiddle-aged healthy individual

Middle-aged healthy individual

Neurogenic disease

Year

Name of Papers

• 2009

  Assessment of the effect of fermented papaya preparation on oxidative damage in spontaneously hypertensive rat brain using electron spin resonance (ESR) imaging and L-band ESR spectroscopy.

  BrainHypertensive ratin vivoBasic researchHigh-blood pressureNeurogenic disease

Neurogenic disease

High-blood pressure

Year

Name of Papers

• 2009

  Assessment of the effect of fermented papaya preparation on oxidative damage in spontaneously hypertensive rat brain using electron spin resonance (ESR) imaging and L-band ESR spectroscopy.

  BrainHypertensive ratin vivoBasic researchHigh-blood pressureNeurogenic disease

High-blood pressure

Blood vessel disease

Year

Name of Papers

• 2012

  Cardioprotective Effect of a Biofermented Nutraceutical on Endothelial Function in Healthy Middle-Aged Subjects.

  Blood vesselMiddle-aged healthy individualin vivoClinical researchBlood vessel diseaseMiddle-aged healthy individual

Blood vessel disease

PNH

Year

Name of Papers

• 2010

  Decreased hemolysis following administration of antioxidant--fermented papaya preparation (FPP) to a patient with PNH

  BloodPNH patientin vivoClinical researchPNH

PNH

β- Thalassaemia

Year

Name of Papers

• 2011

  Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation

  BloodThalassaemia patientin vitroin vivoClinical researchβ- Thalassaemia

• 2010

  The Clinical Effects of Fermented Papaya PreparationR (FPPR) on Oxidative Stress in Patients with HbE/ β -Thalassaemia

  BloodThalassaemia patientin vivoClinical researchβ- Thalassaemia

• 2010

  Amelioration of Oxidative Stress in Red Blood Cells from Patients with β-thalassemia Major and Intermedia and E-β-thalassemia Following Administration of Fermented Papaya Preparation

  BloodThalassaemia patientin vivoClinical researchβ- Thalassaemia

• 2008

  Fermented Papaya Preparation as RedoxRegulator in Blood Cells of β-Thalassemic Miceand Patients

  BloodThalassaemia mouseThalassaemia patientin vitroin vivoBasic researchβ- Thalassaemia

β- Thalassaemia

Wound healing

Year

Name of Papers

• 2012

  Correction of Aberrant NADPH Oxidase Activity in Blood-Derived Mononuclear Cells from Type II Diabetes Mellitus Patients by a Naturally Fermented Papaya Preparation.

  Systemic inflammatoryType II Diabetes Mellitus Patientex vivoClinical researchType II DiabetesWound healing

• 2010

  Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation

  SkinDiabetic mousein vivoBasic researchType II DiabetesWound healing

• 2006

  Plasma glucose level decreases as collateral effect of fermented papaya preparation use.

  Systemic inflammatoryType II Diabetes Mellitus Patientin vivoClinical researchType II DiabetesWound healing

Wound healing

Type II Diabetes

Year

Name of Papers

• 2015

  Does Oral Supplementation of a FPP Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?

  Systemic inflammatoryType II Diabetes Mellitus Patientex vivoin vivoBasic researchType II Diabetes

• 2012

  Correction of Aberrant NADPH Oxidase Activity in Blood-Derived Mononuclear Cells from Type II Diabetes Mellitus Patients by a Naturally Fermented Papaya Preparation.

  Systemic inflammatoryType II Diabetes Mellitus Patientex vivoClinical researchType II DiabetesWound healing

• 2010

  Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation

  SkinDiabetic mousein vivoBasic researchType II DiabetesWound healing

• 2006

  Plasma glucose level decreases as collateral effect of fermented papaya preparation use.

  Systemic inflammatoryType II Diabetes Mellitus Patientin vivoClinical researchType II DiabetesWound healing

Type II Diabetes

Diabetes

Year

Name of Papers

• 2012

  Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population

  Systemic inflammatoryType II Diabetes Mellitus Patientin vivoClinical researchDiabetes

Diabetes

Influenz

Year

Name of Papers

• 2012

  Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects.

  Upper airwayHealthy individual without fitness habitsin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

• 2007

  OXIDATIVE-INFLAMMATORY DAMAGE IN CIRRHOSIS. EFFECT OF VITAMIN E AND A FERMENTED PAPAYA PREPARATION

  LiverCirrhosis patientin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

Influenz

Upper respiratory tract viral infection

Year

Name of Papers

• 2012

  Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects.

  Upper airwayHealthy individual without fitness habitsin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

• 2007

  OXIDATIVE-INFLAMMATORY DAMAGE IN CIRRHOSIS. EFFECT OF VITAMIN E AND A FERMENTED PAPAYA PREPARATION

  LiverCirrhosis patientin vivoClinical researchHealthy individualInfluenzUpper respiratory tract viral infection

Upper respiratory tract viral infection

HCV-related cirrhosis

Year

Name of Papers

• 2011

  EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-α SIGNALLING IN CIRRHOTIC PATIENTS

  LiverCirrhosis patientin vivoClinical researchHCV-related cirrhosis

HCV-related cirrhosis

Alzheimer's disease

Year

Name of Papers

• 2015

  Oxidative Stress in Patients with Alzheimer's Disease: Effect of Extracts of Fermented Papaya Powder

  BrainAlzheimer's patientin vivoClinical researchAlzheimer's disease

Alzheimer's disease