About ORI

About Osato Research Instiute (ORI)

Osato Research Institute (ORI) has been conducting collaborative researches on FPP with various universities and institute in U.S.A. and Europe on the theme of "Healthy Aging" , aimed at achieving to reduce medical costs though preventive medicine. In 2005, we established a Foundation Osato Research Institute in Switzerland in order to make a contribution to the reduction of medical cost and/or expenses in the elderly society.
Here are our greetings, and introduction of researchers and outline of the facility.

Osato Research Institute PresidentYuki Hayashi

Yuki Hayashi
Board of trustee ,Whittier College
Member of president club,The Ohio State University
Secretary General, Japan Office World Foundation of AIDS Research & Prevention

Japan has become a wonderful country of longevity, where 28.4 % of the population is aged 65 or above. On the other hand, the cost of medical care has been increasing every year and it stands about 42.6 trillion yen annually, absorbing national budget. Osato Research Institute (ORI) have been conducting clinical researches on FPP (Fermented Papaya Preparation) for more than twenty years, believing that it is the only solution to reduce medical expenses with Preventive Medicine. The advent of preventive medicine without side effects is expected. Conventionally, medication is prescribed based on doctors' diagnosis. In contrast, preventive medicine is designed for those who are not sick, therefore, it is not precisely in the category of medicine.

My idea of the best preventive medicine is "EDUCATION".

We should provide effective dietary education to young people and let them know that we can prevent diseases by healthy diet and way of life, which will lead to reduction of nation's medical cost. Professor Luc Montagnier, 2008 Nobel Laureate in Physiology or Medicine for his discovery of HIV, and Federico Mayor, ex-Director General of UNESCO, founded the World Foundation of AIDS Research and Prevention (WFARP) to encourage research in developing countries and WFARP Japan Office was founded at ORI in 1998 which has been engaged in preventive activities through AIDS education for children. AIDS is a typical infectious disease preventable through education and knowledge, which, I think, is enormously cost-effective. If we can prevent AIDS and save the medical cost, we can invest more money to education.

The second possibility of preventive medicine is "FERMENTED FOOD" which has been traditionally included in Japanese daily diet.

Japanese fermented foods are considered to be a key to the world's highest longevity of Japanese population. FPP, a powder form of Fermented Papaya, may be a desired candidate preventive medicine. FPP is supported by numerous clinical studies, which show that FPP not only increases anti-oxidant function of our body and reduce inflammation of chronic disease, but also stimulates macrophage activity, promotes NO production and immune function. Recently, the Ohio University team conducted a series of FPP clinical research on diabetic diseases and confirmed that FPP did not affect blood glucose level of diabetic patients although its main component is glucose, and improved immune system and wound closure of the patients by promoting ATP generation and mitochondrial activity. Because of these research results, the invention related to FPP was registered by the Japanese Patent Office on September 14th 2018 as "ATP production promoter, mitochondrial activity promoter, and immunostimulant (Patent Number: 6401792)".

ORI has been focusing on studying for prevention of dementia, which we think would be most cost effective to reduce nation's medical cost. We focus on FPP's possibility to prevent dementia, because we consider that the brain's energy source is glucose and low glucose metabolism in the brain due to aging may be one of the triggers of dementia. Glucose-based FPP can cross blood-brain barrier and improve energy cycle of diabetic patients, so it would be able to improve energy metabolism in the brain. In the clinical study on Alzheimer patients, we confirmed that FPP can significantly reduce their oxidative stress, which is related to progress of the disease. In addition, we obtained the results that FPP could increase cerebral blood flow of Electromagnetic Field Intolerance Syndrome patients and improve their clinical outcomes such as headache or loss of short-term memory. Currently, the Florida University study group studies on FPP to investigate if FPP can improve brain energy metabolism of elderly people and we have been reported that it could improve their memory. Please visit our research pages of our website for more details of our studies.

The third preventive medicine is to provide "A PLACE FOR SOCIAL ACTIVITIES FOR SENIOR GENERATION" with participation in agriculture so that they can be active even after retirement through contact with the community.

In 2012, upon request of the office of Ono-town, we started "Project ORI Wine" for effective use of persimmon fields that had been abandoned due to retirement of elderly farmers in our town. We established beautiful open vineyards in the land of 1000 m2 to grow grapes and make "Bio-Wine (Natural Wine)" with Chardonnay and Pinot Noir. In the beginning, even a viticulture specialist said it would be impossible to grow grapes, especially Pinot Noir, for Bio-wine in such a hot and humid place like Ono-town, however, we have been working hard together with all the employees. Little by little, the vine yards have been expanded and the harvest has been improved with the great help of the local seniors. The local persimmon farmers were also pleased to see the vine yards being good taken care of, because it would also help to prevent disease of persimmons. Our project is beginning to bear fruits in the way of co-existence and co-prosperity with the local farmers. Then, thanks to the efforts of everyone involved, in August 2019, we managed to harvest Pinot Noir and started process of wine-making at last. It takes a lot of time and labor, but if the elderly worker can enjoy taking part in such agriculture in their spare time, they would be able to stay healthy, which would lead to reduce medical costs. It would be the biggest benefit of our project.

Another my dream is a society where senior generation over 60 could go back to school.I hope that such a society can be realized if senior people could enjoy their time as a member of community and stay healthy by going to university or high school wherever their talent and interests lead after their retirement.

We would like to continue to contribute to reduce medical costs in the super aging society based on the three pillars outlined above. I am looking forward to reporting further progress.


Director of Osato Research InstituteDr. Pierre Mantello, PhD, MD

Dr. Pierre Mantello, PhD, MD
Biologist EC4 (European Communities Confederation of Clinical Chemistry)
CES.Bacteriology, Virology, Parasitology, Hematology, and Biochemistry
Gold Medal Graduate, Medical University of Grenoble, France

FPP(Fermented Papaya Preparation) and Inflammaging

Since you're born, you start a fight against your environment where you'll found stressors which are of very different origins. Environmental stressors could be physical, chemical or biological.

Our body is equipped with defenses systems in order to fight against these stressors. Like Claudio Franceschi says, these natural systems of defense are organized in a network of defense functions or antistress responses which are playing a role of anti-aging mechanisms.
Naturally majority of people wants to live a healthy long life. To achieve this goal factors influencing our lifespan are modifiable in order to protect ourselves against environmental stressors.
Protection could be under our decision (modifications of our diet or of our bad habits, modification of our environment) or relative to our genetic equipment (different genetic polymorphisms makes difference between individuals)
New medicines appears recently like predictive medicine which take care of genetic analysis equipment allowing us to know our sensibility and by the way to the risk of having some diseases. This predictive medicine could help to protect us by taking care of factors which could promote diseases at risk.
Preventive medicine by measurement of body parameters (oxidative stress parameters) which are linked with results of environmental stress allows us to protect our body by modifying habits like diet (alimentation , food supplement), by protecting us against sun or pollutants exposure.
In our network defense our main systems are represented by our natural physiological immune and antioxidative systems.
Lifespan had been dramatically increase since the 20th century with progress in conventional medicine (drugs, vaccination, prophylaxis or hygiene). But progress had also comes with increases of stressors like aerial pollution (industrial plants, cars...)as well as pollution inside food (pesticides in water or in food) , radiations ( electro magnetic fields cosmic radiation during long haul flights, Scans, Xrays or radiations due to atomic plant problems)
Exhaustive activities like sport at high level or psychosocial stress due to heavy work are also stressors which are deleterious to our health.
Unfortunately our defense systems are decreasing with age and are overtaken by these accumulation of stressors leading to attacks resulting in acceleration of aging process.
Among these attacks, we have to face particularly to a chronic systemic inflammation which we could call "Inflammaging".
With societies which becomes more and more old, it is necessary to find solutions to protect us in order to stay healthy with age.
Predictive medicine allows us to change our habits in order to decrease risk of diseases we are genetically more sensible.
And preventive medicine allow us to measure results of protection we have taken .
These protections we could take are of different origin.
We could take care of our environment (diminution of pollution exposure when it is possible or intake of food supplement which could help to counteract our diminution of defenses systems.
FPP as food supplement which is able to increase both of our main physiological systems , immune and antioxidative , is one of the best solution to help our body to stay healthy during aging.
Osato Research Institute had performed a lot of clinical studies with FPP and prove the potential of this food supplement to enhance the antioxidative and immune activity which protect our body and allow people to stay healthy during aging.
Inflammaging is the price to pay when we are getting older because keeping a good immune system during aging lead to a chronic production of inflammatory cytokines like TNF alpha , IL6 which are deleterious by create a systemic chronic inflammation which is linked with oxidative stress.
Centenarians are able to maintain a low level of inflammatory cytokines and stay with a low systemic inflammation and keep a long healthy life.
So maintaining a low level of inflammatory cytokines and keeping a low oxidative stress status is a key to stay healthy during aging.
FPP which is able to decrease TNF alpha and IL6 ( study LP) is a food supplement which protect us by maintaining a low level of inflammatory cytokines and could play a interesting role for anti-aging management by fighting against systemic inflammatory called "Inflammaging"
FPP is a food supplement which increase activity of the main antioxidative enzymes like SOD, Gluthation peroxidase and numerous clinical studies support this property.
Oxidative stress is a important factor in many chronic degenerative diseases linked with age like chronic hepatitis, atrophic gastritis, Alzheimer disease, Parkinson, Arteriosclérosis, Cancers... FPP protect us by fighting against oxidative stress and could decrease risk of these degenerative diseases.
During aging our immune system is decreasing ( see figure ), clinical studies ( ) had proved that FPP is able to protect us against risks of infection by increasing the potential of our immune system.
A study recently made in Ohio state University has proved that FPP is able to enhances energy production (ATP) in mitochondria.
This process of energy production is also decreasing during aging. FPP could protect our body against fatigue by helping energy production necessary for main body metabolisms .

FPP is a unique food supplement able to protect us against decrease of our antioxidative and immune systems occurring during aging, but also able to protect us against "Inflammaging" (Chronic systemic inflammation increasing with age) and protect us against aging weakness.
With all these properties, FPP is one of the best candidate to maintain a healthy long life.


Deputy Director of Osato Research InstituteDr. Okuda Sachiko, PhD

Okuda Sachiko PhD
She was graduated from Physical Chemistry Dept. of Ochanomizu Women's University (Japan), and received her MSc degree in physical chemistry from U.C. San Diego(USA) and PhD degree from University of Southampton(UK) for researches on angular distribution of photo-dissociation products, and infrared emission from molecular reactions
She also has held important positions in organizations such as Director(Interim Board Member) of INWES(International Network of Women Engineers and Scientists), President of INWES Japan and Vice President of Japanese Academy of Facial Studies

ORI is a very unique research institute. It is a great inspiration to me that ORI is involved in international research activity but also its involvement in charity activities such as supporting the World Foundation Aids Research and Prevention's Japan Office as well as other social activities for the local children.

The sole focus of our research is "FPP" (Fermented Papaya Preparation) and famous scientists all over the world have been cooperating with our research activities as members of the ORI Scientific Board, to substantiate FPP's effect on immune adjustment with clinical data and its mechanism of involvement in our internal Redox systems. We have members of the board in different fields, in different countries, and each of them communicate their research findings with FPP in international academic meetings, as well as meetings held by the ORI scientific committee. This openly communicates research results and discusses the potential and direction of future research.Our director, Dr. Pierre Mantello is directing FPP research in Europe and has been introducing FPP as an effective food supplement for alternative healthcare in France and Italy. His efforts have made FPP accessible for many people who need it. Although FPP is made in Japan, our research results are still behind compared with the splendid research results in Europe. I would like to launch an initiative for new research projects in Japan to enhance our study.


Osato Research Institute Research Advisor Dr. Kazuhiro Katada,

Dr. Kazuhiro Katada,
Graduated from Osaka Medical College in 1972. After serving as a professor of Hygiene and Medicine at the Fujita Health University, Dr. Kazuhiro Katada was appointed an emeritus professor of the same university in 2013, and an Research Advisor of Osato Research Institute in 2019.
Speciality in Neuroradiology

It is indeed a great honor for me to have the opportunity to work at the Osato Research Institute. I have had the privilege of knowing the ORI's president Mr. Yuki Hayashi for these years and have been always impressed by his personality with great philosophy and excellent ability to take action.

Due to the declining birthrate and longevity promoted by the relatively superior health care system, Japan has been facing a super-aging society like no other in the world. In this situation, FPP is expected to play an important role in supporting positive health. I believe my 45-year career as a radiologist would help  deliver great messages of FPP to all.

Osato Research Institute Principal Researcher Dr. Maki Osato, Ph.D.

Dr. Maki Osato,
Graduated from Collège du Léman, Geneva, Switzerland in 2005 and Whittier College, California, USA in 2010. After completing the doctoral course at the Graduate School of Medicine, Osaka University, she became a Principal Researcher at the Osato Research Institute.
Speciality in Hematology and Oncology

Our institute focuses on preventive medicine using FPP as a tool for well-being. FPP has been registered by the U.S. Food and Drug Administration as a Papaya Dietary Supplement since 2000. Various clinical studies conducted to this day have confirmed that FPP is a safe and unique fermented food to regulate antioxidant, anti-inflammatory and immune functions as well as cellular energy metabolism.

Therefore, FPP can bring better therapeutic effects by combining with conventional treatments and is expected to play a role like a medical food which positions itself between pharmaceuticals and dietary supplements. We will continue working hard on science-based researches to contribute to improve the efficiency of medical care and the quality of life for each individuals.


FPP has gained world recognition.

  • Prof. Luc Montagnier, 
    Prof. Luc Montagnier, MD
  • Prof. Francesco Marotta, 
    Prof. Francesco Marotta, MD
  • Prof. Christiaan Leeuwenburgh, 
    Prof. Christiaan Leeuwenburgh, PhD
  • Prof. Chandan K Sen, 
    Prof. Chandan K Sen, PhD

Outline of ORI

Osato Research Institute

Address of Swiss Foundation: Cours des Bastions 5 CH-1205 GENE`VE SWISS
President: Yuki Hayashi

Address of the institute 1956, Inatomi, Ono-cho Ibi-gun, Gifu, 501-0501, Japan
TEL +81-585-34-3830
FAX +81-585-34-3833
Director Dr. Pierre Mantello, PhD, MD
Activity We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.