We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.

A research paper was published on FPP's control of the growth of a murine melanoma by Dr. Fais et al of Istituto Superiore di Sanità (National Institute of Health) in Italy.

Title of the paper

Oral Administration of FPP Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

Published in Cancers

Click here to download the full paper

Click here to learn more about this paper on our website.

Summary of the published paper is as follows：

Prolonged oxidative stress may play a key role in tumor development. Antioxidant molecules are contained in many foods and seem to have a potential role in future anti-tumor strategies. Among the natural antioxidants the beneficial effect of Fermented Papaya (FPP®) is well known.

The aim of this study was to investigate the effects of orally administered FPP® in either the prevention or treatment of a murine model of melanoma.

The tumor growth was analyzed together with the blood levels of both oxidants (ROS) and anti-oxidants (SOD-1 and GSH).

The results showed that FPP® controlled tumor growth, reducing the tumor mass of about three to seven times vs. untreated mice.

The most significant effect was obtained with sublingual administration of FPP® close to the inoculation of melanoma. At the time of the sacrifice none of mice treated with FPP® had metastases and the subcutaneous tumors were significantly smaller and amelanotic, compared to untreated mice. Moreover, the FPP®anti-tumor effect was consistent with the decrease of total ROS levels and the increase in the blood levels of GSH and SOD-1.

This study shows that a potent anti-oxidant treatment through FPP® may contribute to both preventing and inhibiting tumors growth.