We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.

Why is it recommended to place FPP in mouth and let it dissolve with saliva?

It is because the following effects are expected:

Prevention of upper respiratory tract infection and improvement of immunity

Improvement of enteral environment with maltooligosaccharide, and intestinal immunity regulation

Stimulation of the antioxidant systems recognized by Health Canada

The detailed explanation is stated as below:

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In the clinical trial on FPP to see the effect in common seasonal respiratory tract infection conducted by Prof. Francesco Marotta (University of Milan, Italy) in 2010, FPP supplementation resulted in improvement of immunity, increase of salivary secretion, upregulation of redox gene expression from upper airway cells. Specifically, with FPP supplementation of 9g per a day during 6 weeks, salivary secretion was significantly increased, nearly double in the young age group, and the production level of IgA (biomarker of immunity) and lysozyme (enzyme with bacteriolytic effect) were increased in saliva, and SOD (Superoxide dismutase : enzyme with a key antioxidant role) and phase II enzyme gene expression were upregulated. It suggests that it will hopefully help reducing the incidence and/or severity of upper respiratory tract infection.

Journal of Biological Regulators & Homeostatic Agents Vol. 26, No. 2(2012).
Please click here to read the full-text paper.

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Also, a basic research of the saccharides in FPP conducted by Keiko Nishida, a researcher of Osato Research Institute, showed that some contents of saccharides in FPP increased significantly when they were mixed with saliva in mouth. Specifically, maltose and maltotriose increased respectively 2.4 times and 13.1 times. Maltose and maltotriose are a kind of maltooligosaccharides, which is considered to improve enteral environment and be closely associated with immunity. Therefore, it suggests that mixing FPP with saliva in mouth will help to improve enteral environment and regulate immunity.

This research was presented in the annual meeting of the
Japanese Society of Applied Glycoscience in 2010.
Please click here to read the summary in Journal of Applied Glycoscience.

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Since April 2011, FPP has been officially recognized as Natural Health Product (NHP) by Health Canada and been authorized to make the health claim of "Stimulates the antioxidants systems for the maintenance of good health". NHP is a category for the products between foods and drugs. In order to be recognized as NHP, manufacturers must submit application to Health Canada including information about uses, formulation, dosing, safety and efficacy together with international clinical papers as evidence. Because of the numerous clinical trials and scientific papers on FPP, its property to stimulate the antioxidant systems has been recognized by Health Canada.

The above article is quoted from the Website of OSATO International, Inc. - external website -

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We can see from the above that the effects of placing FPP in mouth and letting it dissolve with saliva are:

Prevention of upper respiratory tract infection and improvement of immunity

Improvement of enteral environment with maltooligosaccharide, and intestinal immunity regulation

Stimulation of the antioxidant systems recognized by Health Canada

We can expect such beneficial effects of prevention of disease and maintenance of good health.