About ORI

About Osato Research Instiute (ORI)

Osato Research Institute (ORI) has been conducting collaborative researches on FPP with various universities and institute in U.S.A. and Europe on the theme of "Healthy Aging" , aimed at achieving to reduce medical costs though preventive medicine. In 2005, we established a Foundation Osato Research Institute in Switzerland in order to make a contribution to the reduction of medical cost and/or expenses in the elderly society.
Here are our greetings, and introduction of researchers and outline of the facility.

Osato Research Institute PresidentYukiyasu Hayashi

Japanese society is rapidly becoming a nation of the most serious aging population in the world, with those who are 65 years old and older accounting for about a quarter of the population by 2015. Japan has reached one of the world's top level countries for longevity, having an average life span of 86.61 years for women and 80.21 years for men. However, on the other hand, the cost of medical care has been increasing every year and it stands about 40 trillion yen annually, absorbing a half of her national budget. The situation of 'childless, aging population' is now an inescapable reality, so that we have to manage reduction in medical expenses by any cost.

Conventional medicine has been developed with the aim of treating patients for their illness. Medication is prescribed according to the law, based on doctors' diagnosis, and its effect may be confirmed in a reasonable, short period of time. In contrast, since preventive medicine is not designed for sick people in particular, it is generally difficult to decide what should be deemed as its effect. However, in order to achieve bold reduction in medical expenses, it should be necessary to develop preventive medicine to avoid becoming ill. If we can prevent diseases before they occur, a healthy older population in the workforce would be naturally increased. If elderly people can work in good health with their retirement age extended to 70, and given an opportunity to share their proficient amount of knowledge and skills, as well as technology with younger generations, Japan would be able to offer a new direction for the near future of aging societies, as a member of the most developed nations.

My idea of the best preventive medicine is EDUCATION.

AIDS is an infectious disease, which is preventable through education and knowledge. The cost of treating someone with HIV in Japan is now estimated at around 2,000,000 yen (nearly 15,000 euro) per year. The recent medical advance allows people with HIV to live a normal life, although they cannot be really cured; they need medication every single day throughout their entire life. Taking my home province, Gifu-prefecture, for instance, approximately 10 new cases of HIV infection are reported every year. The medical cost of HIV treatment for 10 people for 20 years would amount to 400 million yen (2,000,000 yen ×10 people×20 years) in Gifu-prefecture alone; to be started with 400 million, and then 800 million.... We may invest this money in infrastructure needed for aging society by preventing 10 young people a year from HIV infection. We founded World Foundation Aids Research and Prevention Japan Office in 1998 with Prof. Luc Montagnier, 2008 Nobel Laureate in Physiology or Medicine for his discovery of HIV, and have been engaged in preventive activities through AIDS education for children in elementary and junior high school. AIDS is just one example among many infectious or chronic diseases preventable through education, which, I think, is enormously cost-effective.

The second preventive medicine is ancestral Good-for-Your-Body Food.

Conventional medicine is prescribed only for sick people, against which the benefit of food is for all the people. You can prevent form becoming ill by eating the right foods for your body. The Osato Research Institute considers that ancient Japanese fermented foods may be a key to the world's highest longevity of Japanese population, and that FPP (Fermented Papaya Preparation) may be a desired candidate preventive medicine. Many clinical trials have been conducted on FPP, which was born through the combination of Papaya, known as a health fruit and Japanese traditional fermentation techniques. We wish to make a contribution to the reduction of medical cost and/or expenses through the product of FPP.

It is estimated that in Japan 4.62 million people, 1 in 7 elderly over 65, suffer from dementia in 2012, and that 7 million people, 1 in 5 elderly over 65 will do so in 2025. Curative medicine for dementia has not yet been developed, and we are told, most of medical expenses are personnel expenses related to employment of care workers for patients. If this goes on, it might turn out somehow astronomical sums of money in the near future.

We are conducting clinical researches to verify the effect of FPP on patients of Alzheimer and Parkinson diseases as to whether or not their progress being checked, and we are pleased to note reports of positive results. In addition, we have been conducting on the effect of FPP on diabetic patients; it is suggested that people suffering from diabetic have increased risk of dementia, and herein, we are getting good results, too. Based on these clinical researches, we would like to advance FPP research and wish to render services for creation of a bright society in Japan.
Thank you for your support.

Yukiyasu Hayashi
Board of trustee ,Whittier College
Member of president club,The Ohio State University
Secretary General, Japan Office World Foundation of AIDS Research & Prevention

Senior Director of Osato Research InstituteProf. Eliezer A. Rachmilewitz, MD

I feel honored to be the senior director of the Osato Research Institute.

I assumed the position because Mr. Hayashi is one of my longtime friends and I fully appreciate his idea to reduce medical cost in the aging society, which is the main reason why ORI was established.

I have been interested for years in congenital and acquired hemolytic anemias where oxidative stress is playing a major pathophysiological role. This is how I became involved in studying the effects of FPP (Fermented Papaya Preparation) which is a very unique food capable of adjusting oxidative stress within a living organism with a concomitant increase in antioxidant enzymes in the body such as Gluthatione (GSH).

I think that FPP can be used in a variety of disorders where oxidative stress is playing a role alone or in combination with other drugs.

I have used FPP to treat patients with thalassemia and showed amelioration of parameters of oxidative stress. (Amer J et al. "Fermented Papaya Preparation as an antioxidant in blood cells of beta thalassemic mice and patients." Phytotherapy Research. 22:820-828, 2008).

I am planning to extend the studies with FPP to other disorders such as diabetes, arteriosclerosis and neurodegenerative disorders, etc...

Prof. Eliezer A. Rachmilewitz MD
Graduated Hebrew University.
Hebrew University, Hadassah Medical School, Jerusalem
Internship - Hadassah University Hospital and Rambam Hospital

1961:Received MD Degree
1976:Acting Head, Hematology Service, Hadassah University Hospital
1978-1980:Head, Hematology Service, Hadassah University Hospital
1981-2000:Head, Department of Hematology, Hadassah Medical Organization
April 1999-present:Head, Hematology Institute, Wolfson Medical Center

Director of Osato Research InstituteDr. Pierre Mantello, PhD, MD

Immun'Âge and Inflammaging

Since you're born, you start a fight against your environment where you'll found stressors which are of very different origins. Environmental stressors could be physical, chemical or biological.
Our body is equipped with defenses systems in order to fight against these stressors. Like Claudio Franceschi says, these natural systems of defense are organized in a network of defense functions or antistress responses which are playing a role of anti-aging mechanisms.
Naturally majority of people wants to live a healthy long life. To achieve this goal factors influencing our lifespan are modifiable in order to protect ourselves against environmental stressors.
Protection could be under our decision (modifications of our diet or of our bad habits, modification of our environment) or relative to our genetic equipment (different genetic polymorphisms makes difference between individuals)
New medicines appears recently like predictive medicine which take care of genetic analysis equipment allowing us to know our sensibility and by the way to the risk of having some diseases. This predictive medicine could help to protect us by taking care of factors which could promote diseases at risk.
Preventive medicine by measurement of body parameters (oxidative stress parameters) which are linked with results of environmental stress allows us to protect our body by modifying habits like diet (alimentation , food supplement), by protecting us against sun or pollutants exposure.
In our network defense our main systems are represented by our natural physiological immune and antioxidative systems.
Lifespan had been dramatically increase since the 20th century with progress in conventional medicine (drugs, vaccination, prophylaxis or hygiene). But progress had also comes with increases of stressors like aerial pollution (industrial plants, cars...)as well as pollution inside food (pesticides in water or in food) , radiations ( electro magnetic fields cosmic radiation during long haul flights, Scans, Xrays or radiations due to atomic plant problems)
Exhaustive activities like sport at high level or psychosocial stress due to heavy work are also stressors which are deleterious to our health.
Unfortunately our defense systems are decreasing with age and are overtaken by these accumulation of stressors leading to attacks resulting in acceleration of aging process.
Among these attacks, we have to face particularly to a chronic systemic inflammation which we could call "Inflammaging".
With societies which becomes more and more old, it is necessary to find solutions to protect us in order to stay healthy with age.
Predictive medicine allows us to change our habits in order to decrease risk of diseases we are genetically more sensible.
And preventive medicine allow us to measure results of protection we have taken .
These protections we could take are of different origin.
We could take care of our environment (diminution of pollution exposure when it is possible or intake of food supplement which could help to counteract our diminution of defenses systems.
Immun'Âge as food supplement which is able to increase both of our main physiological systems , immune and antioxidative , is one of the best solution to help our body to stay healthy during aging.
Osato Research Institute had performed a lot of clinical studies with Immun'Âge and prove the potential of this food supplement to enhance the antioxidative and immune activity which protect our body and allow people to stay healthy during aging.
Inflammaging is the price to pay when we are getting older because keeping a good immune system during aging lead to a chronic production of inflammatory cytokines like TNF alpha , IL6 which are deleterious by create a systemic chronic inflammation which is linked with oxidative stress.
Centenarians are able to maintain a low level of inflammatory cytokines and stay with a low systemic inflammation and keep a long healthy life.
So maintaining a low level of inflammatory cytokines and keeping a low oxidative stress status is a key to stay healthy during aging.
Immun'Âge which is able to decrease TNF alpha and IL6 ( study LP) is a food supplement which protect us by maintaining a low level of inflammatory cytokines and could play a interesting role for anti-aging management by fighting against systemic inflammatory called "Inflammaging"
Immun'Âge is a food supplement which increase activity of the main antioxidative enzymes like SOD, Gluthation peroxidase and numerous clinical studies support this property.
Oxidative stress is a important factor in many chronic degenerative diseases linked with age like chronic hepatitis, atrophic gastritis, Alzheimer disease, Parkinson, Arteriosclérosis, Cancers... Immun'Âge protect us by fighting against oxidative stress and could decrease risk of these degenerative diseases.
During aging our immune system is decreasing ( see figure ), clinical studies ( ) had proved that Immun'Âge is able to protect us against risks of infection by increasing the potential of our immune system.
A study recently made in Ohio state University has proved that Immun'Âge is able to enhances energy production (ATP) in mitochondria.
This process of energy production is also decreasing during aging. Immun'Âge could protect our body against fatigue by helping energy production necessary for main body metabolisms .

Immun'Âge is a unique food supplement able to protect us against decrease of our antioxidative and immune systems occurring during aging, but also able to protect us against "Inflammaging" (Chronic systemic inflammation increasing with age) and protect us against aging weakness.
With all these properties, Immun'Âge is one of the best candidate to maintain a healthy long life.

Dr. Pierre Mantello, PhD, MD
Biologist EC4 (European Communities Confederation of Clinical Chemistry)
CES.Bacteriology, Virology, Parasitology, Hematology, and Biochemistry
Gold Medal Graduate, Medical University of Grenoble, France

Deputy Director of Osato Research InstituteDr. Okuda Sachiko, PhD

ORI is a very unique research institute. It is a great inspiration to me that ORI is involved in international research activity but also its involvement in charity activities such as supporting the World Foundation Aids Research and Prevention's Japan Office as well as other social activities for the local children. The sole focus of our research is "FPP" (Fermented Papaya Preparation) and famous scientists all over the world have been cooperating with our research activities as members of the ORI Scientific Board, to substantiate FPP's effect on immune adjustment with clinical data and its mechanism of involvement in our internal Redox systems. We have members of the board in different fields, in different countries, and each of them communicate their research findings with FPP in international academic meetings, as well as meetings held by the ORI scientific committee. This openly communicates research results and discusses the potential and direction of future research.Our director, Dr. Pierre Mantello is directing FPP research in Europe and has been introducing FPP as an effective food supplement for alternative healthcare in France and Italy. His efforts have made FPP accessible for many people who need it. Although FPP is made in Japan, our research results are still behind compared with the splendid research results in Europe. I would like to launch an initiative for new research projects in Japan to enhance our study.

Okuda Sachiko PhD
She was graduated from Physical Chemistry Dept. of Ochanomizu Women's University (Japan), and received her MSc degree in physical chemistry from U.C. San Diego(USA) and PhD degree from University of Southampton(UK) for researches on angular distribution of photo-dissociation products, and infrared emission from molecular reactions
She also has held important positions in organizations such as Director(Interim Board Member) of INWES(International Network of Women Engineers and Scientists), President of INWES Japan and Vice President of Japanese Academy of Facial Studies


FPP has gained world recognition.

  • Prof. Lester Packer ,PhD
    Prof. Lester Packer ,PhD
  • Prof. Luc Montagnier, MD
    Prof. Luc Montagnier, MD
  • Prof. Francesco Marotta, MD
    Prof. Francesco Marotta, MD
  • Prof. Christiaan Leeuwenburgh, PhD
    Prof. Christiaan Leeuwenburgh, PhD
  • Prof. Chandan K Sen, PhD
    Prof. Chandan K Sen, PhD

Outline of ORI

Osato Research Institute

Address of Swiss Foundation: Cours des Bastions 5 CH-1205 GENE`VE SWISS
President: Yukiyasu Hayashi

Address of the institute 1956, Inadomi, Ono-cho Ibi-gun, Gifu, 501-0501, Japan
TEL +81-0585-34-3830
FAX +81-0585-34-3833
Director Dr. Pierre Mantello, PhD, MD
Activity We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.