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Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population

(1) Jhoti Somanaha, (2) Okezie I Aruomab, (3) Teeluck K.Gunnessc, (4) Sudhir Kowelssrd, (5) Venkatesh Dambalae, (6) Fatima Muradf, (7) Kreshna Googoolyeg, (8) Diana Daush, (8) Joseph Indelicatah, (9) Emmanuel Bourdoni, (1) Theeshan Bahoruna

(1) ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, Reduit, Republic of Mauritius
(2) School of Biomedical Sciences and School of Pharmacy, American University of Health Sciences ,Signal Hill,CA,USA
(3) Cardiac Centre, Sir Seewoosagar Rangoolam National Hospital(SSRNH), Pamplemousses Mauritius
(4) Non Communicable Diaseses Unit(NCD), Ministry of Health and Quality of Life ,Mauritius
(5) Department of Biochemistry, Apollo Bramwell Hospital, Moka, Mauritius
(6) Centre for Clinical Research and Education, Apollo Bramwell Hospital, Moka, Mauritius
(7) Human Resource Development Council, NG Tower, Ebene, Mauritius
(8) Department of Occupational Therapy, Touro College of Health Sciences, Bay Shore, New York, USA
(9) Groupe d'Etude surl'Inflammation Chronique et I'Obesite(GEICO),Universite de La Reunion, Plateforme CYROI,France

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Clinical evidence and cellular models have shown an inverse relationship between the intakes of plant and fruit based diets and oxidative stress, suggesting the suitability of natural antioxidants in the management of diabetes mellitus and its complications. A randomized controlled clinical trial was conducted at the Cardiac Centre, SSRN Hospital, Pamplemousses, (Mauritius) to determine the effect of a short term supplementation of a fermented papaya preparation (FPPR) on biomarkers of diabetes and antioxidant status in a multi-ethnical neo-diabetic population from November 2010 to March 2011. Supplementation of 6 g FPPR/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes. When comparing experimental to control groups with independent samples t-test, C-reactive protein levels significantly decreased (P=0.018), LDL/HDL ratio was considerably changed (P=0.042), and uric acid levels were significantly improved (P=0.001). ANOVA results also validated the same findings with significant differences in C-reactive protein, LDL/HDL ratio, uric acid and in serum ferritin levels. FPPR may present a novel, economically feasible nutraceutical supplement for themanagement of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress.

【Table1】Effect of a fermented papaya preparation on a neo-diabetic Mauritian population under the FPPR and control regimens (N=41) during the intervention period November 2010 to March 2011 Significance testing as Independent samples T-test amongst the pre and post supplementation groups when comparing experimental and control groups .

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Preventive Medicine 54 (2012) S90-S97

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