We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.

Prof. Dominique Belpomme at Paris University in France is a leading researcher on electromaginetic hypersensitivity (EHS), which causes those who are highly sensitive to electromagnetic field exposure various symptoms including headache, nausea or sleep disturbances even with exposure to weak electromagnetic from daily devices such as smartphone or microwave oven. He published a research paper on FPP in the journal called "Functional Foods in Health and Disease" on February 28, 2019.

For more information: http://en.ori-japan.com/news/research/research-paper-published-on-electromagnetic-field-intolerance-syndrome-emfis-which-has-no-recognized.html

On March 2020, Prof. Belpomme published his latest paper "Electrohypersensitivity as a Newly Identified and Characterized Neurologic Pathological Disorder: How to Diagnose, Treat, and Prevent It" in International Journal of Molecular Sciences. In this paper, he indicates that WHO had stated that EHS could not be diagnosed medically because of "no clear diagnostic criteria", however, it is becoming a new insidious worldwide plague involving millions of people and they asked the WHO to include EHS as a neurologic disorder in the international classification of diseases. He also stated that there is, at the moment, no recognized standardized treatment of EHS. There are, however, some treatments that could be indicated, on the basis of biological investigations and recommended FPP as one of effective treatments.

Excerpt from section 7 "Treatment and Prognostic Evolution" regarding FPP research is shown below:

"We showed that natural products such as fermented papaya preparation (FPP) can restore brain pulsatility in the various middle cerebral artery-dependent tissue areas of temporal lobes, thereby improving brain hemodynamics and, consequently, brain oxygenation. Since FPP was shown to possess some antioxidant, anti-inflammation, and immune-modulating properties, we recommend the use of this widely available natural product."

Example of diagrams obtained from the database by using UCTS exploring the global centimetric ultrasound pulsatility in the two temporal lobes of an EHS subject at inclusion (Ti) and three months later (T3) after fermented papaya preparation (FPP) supplementation (9 g per day in two divided doses).

1) Beneficial effects of a Fermented Papaya Preparation for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis: Functional Foods in Health and Disease 2018; 8(2):122-144

2) Electrohypersensitivity as a Newly Identified and Characterized Neurologic Pathological Disorder: How to Diagnose, Treat, and Prevent It.: International Journal of Molecular Sciences 2020 Mar 11; 21(6)