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2014/10/30ResearchResearch Results

World's first reporting! Study group of Ohio State University finds out that FPP improve immune system of diabetic patients

Published in Antioxidants & Redox Signaling Journal on September 30, 2014

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The Osato Research Institute guesses that it is diabetic patients who need sugar more than any other patients in the world, and that if they could convert sugar into energy without having sugar left in their bodies, it would help to maintain their immune system. And, from a number of clinical studies over the past, we infer that FPP can be a strong candidate to make it possible.

The study group of Ohio State University first tested if sugar-based FPP is safe for consumption by diabetic patients. After demonstrating the safety, they started their clinical study.

As a result of this clinical study, it was confirmed for the first time in the world that FPP improves the immune system of diabetic patients.

They also reported that FPP may increase energy inside the cell resulting from stimulation of mitochondrial respiration, as well as promotion of cellular ATP generation. This may be linked with an important mechanism of FPP's anti-inflammatory effect obtainable by stimulating antioxidant and immune systems.

Abstract of the published paper is as follows:
FPP is a nutritional supplement reported act as an antioxidant by scavenging reactive oxygen species (ROS) and removing 'bad ROS', while inducing "respiratory burst" production of necessary 'good ROS'. We sought to investigate the safety of oral administration of FPP (9g/d, 6 weeks) to T2D patients with respect to its effect on the hyperglycemia status of these patients. Peripheral blood was collected during a baseline visit, followed by subsequent collections during and after supplementation.
Induced "respiratory burst": ROS production was measured at each visit, in addition
to fasting blood glucose, lipid profile, glycated hemoglobin (HbA1c), and lipid/protein peroxidation. Oral FPP supplementation induced "respiratory burst" in peripheral blood mononuclear cells while not influencing other blood parameters studied. When human monocytic THP-1 cells were supplemented with sugar-based FPP, cellular ATP and NADPH concentrations were increased, while matched glucose alone did not produce similar effects, suggesting a glucose-independent component of FPP to be responsible for increasing cellular energetics. THP-1 cells supplemented with FPP also exhibited higher mitochondrial membrane potential (Δψm) and oxygen consumption as compared to cells treated with glucose alone. Taken together, our observations lead to the hypothesis that FPP corrects inducible "respiratory burst" function in type 2 diabetes patients.

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FPP elevated intracellular ATP and NADPH levels.


Fig.04.jpg
FPP increased mitochondrial membrane potential and O2 consumption.