Alice Powell took the Graduate Cup win in round 12 of the Formula Renault UK Championship at Snetterton, this weekend, as well as finishing 7th and 4th outright, in the two races. This was the first time the Formula Renault Championship had raced at the new Snetterton Circuit.

In first qualifying, Alice struggled, going off the track a couple of times, and ended up only P9 on the time sheet. However, in the second qualifying, she produced a lap that put her 4th on the grid, "I am not too sure what went on in Q1, but I struggled. That was very disappointing, but Q2 was great and put me in a great position for challenging for a podium!"

For Race One, Alice got a reasonable start, but was not in a position to challenge the guy in front. From then on, the race was pretty much follow the leader, and it was only when others on front made mistakes, that Alice took the advantage to gain the position. She crossed the line only a few tenths behind 6th place.

For Race Two, she lined up in 4th place. Getting a good start, she challenged Tio Ellinas, who was in 3rd. However, at the Agostini Hairpin, Alice got hit from behind by Daniel Cammish, damaging the battery plug at the back of the car. Luckily, Alice carried on, losing not a great deal of time. On the first lap, Jack Hawksworth had a heavy impact with the safety barriers, causing the safety car to be deployed.

After 3 laps behind the safety car, the racing then continued, but oversteer at the first corner, saw Powell lose a large chunk of time from the cars in front, which meant she had to heavily defend from the cars behind her. But, she stuck at it, and managed to pull out a small gap and push to catch the guys in front.

With six laps remaining, exiting the Hamilton corner, the car lost all power for a split second, only to see the gap Alice pulled out from Cammish, close, and exiting the final corner she had a train of 3 cars right on her tail. Having thought she had seen off the attack from Cammish, her car cut out again, this time for slightly longer, allowing Oliver Rowland to pull alongside her. However, Rowland, thinking he was clear of Alice's car, pulled over to the inside, clipping Alice's right front wheel, causing him to go wide, which allowed Alice back through.

From then on, Alice got her head back down and pulled another small gap in 4 laps, to cross the line in 4th place, for the Manor squad and taking the Graduate Cup victory.
Speaking about the weekend, Alice commented "It has been another mixed weekend for me. I have still learnt a lot from the weekend and to come away with some decent point and the Graduate win is great! Race One, not much went on, but Race Two, kept me on my toes, especially with the car cutting out on occasions! I think I would have pulled a much bigger gap from Dan (Cammish), and even stood a chance for challenging for 2nd or 3rd if I did not had the problem, which was caused by the contact from behind at the start. Big thanks to everyone at Manor for their help, who continue to work so hard and do a great job. I am very much looking forward to Silverstone, which is in two weeks!"

Alice's race engineer and Manor co-owner, Sarah Shaw said "After all the bad luck Alice has had so far this season it's great to see her finally rewarded with a good result and Graduate Cup win. She drove a great race and kept a cool head, despite having to soak up enormous pressure when her car began to cut out as a result of damage to the electrics when she was hit from behind at the start".

Alice's next outing is in one week (20/21 Aug), at the Silverstone Arena Circuit. It will be support to the World Series By Renault Championship, which attracts crowds of over 100,000.

　　

ＰｒｏｊｅｃｔⅠ
June 10th
Barcelona, Spain SHA (www.shawellnessclinic.com)
We held a press conference at the Resort Wellness Clinic. Under the chairwomanship of Princes Beatrice, Mr. Hayashi expressed his thanks for the international support of Japan including Spain, and reported on the present state of things in Japan. He emphasized the importance and economic effect of prevention for diseases as well as for natural disasters.
Wellness Clinic SHA started a treatment, using Immun'Age as one of their clinic menus this June.

ＰｒｏｊｅｃｔⅡ
June 15th to 17th
Paris, France
The 4th International Symposium for Nutrition, Oxygen Biology and Medicine was held at Campus des Cordeliers in Paris, and more than 200 doctors from the whole world, both in the field of basic study and clinical study, participated in this symposium.
At the request of President of the symposium, Osato Research Institute held a Charity Concert by a Japanese Pianist on June 16th at Maison des Arts et Métiers for the earthquake and tsunami in Japan.
Ms. Makiko Hayashi, a graduate student of Osaka University's School of Medicine, made a speech both in French and English and gave the message of her father, Mr. Hayashi, President of Osato Research Institute.

ＰｒｏｊｅｃｔⅢ
June 18th to 22nd
Tokyo, Japan
The Osato Research Institute invited two French leading scientists in cooperation with the French Embassy in Japan, while there is a decrease in the number of celebrated scientists visiting Japan after the earthquake: They are Prof. Luc Montagnier, the winner of 2008 Nobel Prize in Medicine and Physiology, and Dr. Gerald Salama, who is known as an expert in preventive medicine.
On June 21st, at the end of the lecture titled " Status and Future Prospective of Anti-Aging Medicine" at MAISON FRANCO-JAPONAISE in Tokyo, Prof. Motagnier, as a member of O.R.I Scientific Board, handed the Osato Research Institute's "HEART FOR JAPAN FUNDS" of 1,000,000 yen to 'NPO Ashinaga'. Prof. Montagnier is worried about the children who have lost their parents in the earthquake and tsunami, and the fund will be used to build a care house for these children by 'NPO Ashinaga'. Following the lectures, we were grateful to receive donation of 35,453 yen from the audience and to send them to 'NPO Ashinaga', too.

ＰｒｏｊｅｃｔⅣ
June 25th to 26th
Nürburgring, Germany
Aston Martin, a leading British Car maker, proud of one hundred year long history and its car used for the latest Royal Wedding, stood up for Japan with Japanese flags. Aston Martin entered the race with its factory team.
The three entry cars are V12 "Zig", "Zag" and V8 VantageN24. All of the three appeared on the Nürburgring circuit with Japanese flags on their roofs, which made all the Japanese present there shed tears and appreciate their thoughtfulness.
Dr. Bez, CEO of Aston Martin, handed a ￡100,000 check to Mr. Akio Toyoda, president of Toyota Motor Corporation, who has been in the same pit for 5 years.

ＰｒｏｊｅｃｔⅤ
June 27th
OSAKA University Medical School
Prof. Rachmilewitz, who is senior director of Osato Research Institute and a home doctor of Israeli prime minister, visited Japan and gave a lecture in the 4th MEET THE EXPERT in blood diseases at Osaka University Medical School held at the sponsor of Pfizer Japan Inc.
In Japan, the theme of "blood and oxidative stress" is rather new, a subject to be studied from now on, the professors at Osaka University Medical School were found, listening to his lecture with great interest.
The clinical study of Prof. Rahmilewitz was announced in the form of a treatise for FPP (Immun'Age) to control ROS (oxidative stress) in the blood of patients suffering from blood diseases and to increase the effect of GSH(glutathione), a useful enzyme or ferment for ROS simultaneously.

Open to public, no admission charge

We explained to the children that we research on how to stay healthy as we get older and how to recover from physical burden such as tough sports, etc.
We hope that some of them will take interest in science and develop their interest in the filed of science.

"One of our laboratory fellows received Nobel Prize!"　 "Wow...It's great!" They were taking notes on what raised their interests.	They can not understand some difficult words, but their eyes were shining with willingness to get to know things.
They were listening to the explanation on the painting "water" of Otohiko Katagiri , which was donated to the Osato Research institute by the painter.	They seemed to have enjoyed their unusual experience of visiting us, especially listening about our researches and looking at the laboratory. We hope to see them again!

Since the occurrence of the FUKUSHIMA Nuclear Power Plant accident, due to the greatest earthquake and tsunami in that has ever been experienced in Japan, the effect that radioactivity has on body has been drawing a lot of attention around the world. The environmental radioactivity level in Tokyo was 0.8μSv/h just after the Fukushima hydrogen explosion on March 15th in Tokyo. This is about one-tenth of the aforementioned radiation dose received during a long flight and recorded only temporarily. Although this figure came back normal to 0.028～0.079μSv/h and the average of April 21th is 0.072μSv/h, many people remained anxious about the harzards presented by the potential exposure.

Therefore, we decided to transmit an emergency message regarding the effect of radiation to the human body and the effectiveness of FPP against the damage.

The action pathway of radiation to the human body can visualized in two ways: one is direct action and the other one is an indirect action. (Figure 2) The direct action is DNA breakage. DNA has essential information to make body. The damaged DNA would cause apoptosis and mutation of cells and increase a risk of diseases. (Figure 3) The indirect action is generation of radical oxygen in the human body. We are influenced by radiation not only through environment exposure but also through breathing air and eating food. The DNA base damage mediated by radical oxygen would disturb normal cell growth and cause a functional decline of the body.

FPP adjust the functions of anti-oxidant systems and immune systems and many papers on the clinical trials have been presented. FPP can prevent DNA damage and inflammation as well as reduce the risk for developing diseases and helps the quick recovery of damaged tissues in the human body.

Normal cellular metabolism is widely acknowledged as the source of endogenous reactive oxygen species (ROS), and it is these cellular processes that are largely responsible for the background levels of oxidative DNA damage detected in normal tissue. ROS may also be generated by ionizing or ultraviolet radiation. Equally, certain exogenous chemicals may redox cycle following metabolism by the cell, with the subsequent production of electrons that can be transferred to molecular oxygen producing the superoxide anion (a free radical denoted as O2•-). Dismutation of the superoxide anion generates the hydrogen peroxide inside the cells and tissues and these together with the complex interaction with other ROS (such as the reactive hydroxyl radical) can damage cellular biomolecules, such as DNA, leading to modification and potentially serious consequences for the cell if the DNA damage is not repaired. One such DNA oxidation product is 8-hydroxydeoxyguanosine (8-OH-dG). It is most notable that FPP consumption reduces 8-OHdG levels and this is an important biomarker outcome for DNA damage, and controls DNA adduct, which may impact the progression towards the development of cancer. FPP consumption is associated with gene expression of SOD (an enzyme responsible for the elimination of the superoxide anion), as well as hOGG1 (a DNA repair enzyme responsible for the elimination of 8-OHdG from oxidative DNA). That both enzymes are involved with biological repair and defense system of our own body, suggests that FPP has functions that are highly beneficial to human health.
Further, FPP has potential to reduce the risk of developing disease due to oxidative DNA damage.Research at ORI will continue to define the potential defense function of FPP against radiation induced physiological changes as in chronic human diseases.

- FPP Papers on DNA damage and Anti-oxidation -

◆Anti-oxidant effect

◆Anti-inflammatory effect

◆Gene Expression

◆Reference Review Article

◆Reference Book

Osato Research Institute, together with the researchers from Europe, U.S.A. and Israel and other parts of the world, has decided to make contribution to assist those who have been affected by this disaster and to aid in the recovery through charity organizations such as the Japanese Red Cross Society.

The Lord Wakefield Trophy, which was first presented to the Women's Automobile Sports Association (WASA) in 1929, by Lord Wakefield, was handed over to the British Women's Racing Drivers' Club (BWRDC) after its creation in 1962 by Mary Wheeler MBE. It is now acknowledged as the club's premier award with previous recipients including Divina Galica, Susie Stoddart, Amanda Whitaker, Rachel Green, the late Pat Moss-Carlsson, Michelle Mouton, Louise Aitken-Walker and Jutta Kleinschmidt, Sarah Moore.

July 22nd 2010 UNESCO Paris

On July 22, the ORI held a workshop on "Nutritional Approach to Preventive Medicine by FPP" at the UNESCO, Paris. Before starting the workshop, Mr. Hayashi, president of Osato Research Institute, welcomed the members of the ORI board with his message; "In Japan, more than 23 % of the population is over 65 years old. Japan is one of the super-aging societies. In near future, the most of the country's tax revenue will have to cover the expanding medical cost. The only solution to avoid it is disease prevention. Especially it is important to prevent chronic diseases. We have been researching the relation between intravital inflammation and chronic diseases. We have found that FPP has anti-inflammatory effect and believe that FPP has big potential for disease prevention. Today, I thank you all to be here and expect good research presentations, which would lead to reduce medical costs. Lastly, I appreciate that Prof. Montagnier, the 2008 Nobel Laureate, accepted to serve as our chairman today."

Despite it was summer holiday season, 8 (out of 10) members of the board attended this workshop at UNESCO.	It started with greeting from the chairman, Prof. Montagnier, the 2008 Nobel Laureate.
Prof.Chandan from Ohio University made a presentation on FPP's effect on would healing and its mechanism, explaining why diabetic patients heal wounds poorly.	Dr. Okezie from Touro Collegeof Pharmacy-New York presented his plan of a massive-scale clinical trial of the diabetics using FPP.
Prof. Lucia from Pisa University made a presentation on her clinical trial of FPP's effect on prevention of Alzheimer disease. The study has been going on for three years.	Prof. Rachmilewitz explained about hematological disorder associated with anemia from the viewpoint of oxidative stress.
They never stop discussion even during teatime.	Together with Prof. Montagnier in his room at UNESCO
It's time to go for lunch!