Immun' Age(FPP) Osato Research Institute

Flash Report!!ASTON MARTIN CELEBRATES DOUBLE VICTORY AT SILVERSTONE

2013-04-16T03:06:13Z

Aston Martin Racing's 2013 FIA World Endurance Championship (WEC) programme got off to a near perfect start at the Six Hours of Silverstone today (14 April) with a double victory in the GT class.

From the left：Bruno Senna, Stefan Mücke, Darren Turner

The #97 V8-powered Vantage GTE, driven by Darren Turner (GB), Stefan Mücke (D) and Bruno Senna (BR), finished in first place in the GT Pro category, while the #95 car of Danish trio Christoffer Nygaard, Kristian Poulsen and Allan Simonsen triumphed in the GT Am class.

At Aston Martin Racing's home round of the WEC in Northamptonshire, UK, Pedro Lamy (PT), Paul Dalla Lana (CN) and Frédéric Makowiecki (FR) also put in an impressive performance with third position in the #99 car in GT Pro, crossing the line a single lap behind the #97 machine and within 13 seconds of the second-placed car after six hours.

4The fourth Gulf-liveried Aston Martin, the #96 car of Jamie Campbell-Walter (GB), Roald Goethe (D) and Stuart Hall (GB), finished fourth in GT Am having been in contention for a podium for the entire race.

After a successful qualifying on Saturday, which saw the team secure first and second position in both GT categories, Aston Martin Racing further proved its class-leading pace by setting the fastest lap of all the GT runners; the #99 car recorded a best lap of 2:01.426 after five hours, although competitor cars were very close behind in a super-competitive category.
While celebrating a near perfect start to Aston Martin Racing's world championship bid with a faultless lights-to-flag victory, Darren Turner said: "That was an amazing result! We couldn't have asked for a better start to the season.

Stefan, Bruno and myself all pushed hard throughout what was, at times, a difficult race. However, the car was prepared perfectly with a lot of hard work and the result is a great reward for everything.
Praise to our chief engineer, Dan Sayers, who has done a great job with the 2013 car and given us a package that should see us have a solid season."

Making his WEC debut, Bruno Senna added: "I'm really happy to start my GT career with a win.
It's been great joining Aston Martin Racing and to get a pole position and win and go home from our first WEC race of the year with so many points for the championship is unbelievable.
It was a tough race;
we had to push hard while avoiding accidents, but my team did a great job.
We must now keep pushing hard; the competition here is very, very strong."
Allan Simonsen, speaking for the #95 GT Am-winning car, comments:
"I'm very happy on behalf of the whole team.
It was a big push to get us here and to start the season with points is fantastic.
To do it on Aston Martin Racing's home turf is even better; we couldn't be happier."

John Gaw, Team Principal at Aston Martin Racing, concluded:
"Today's outcome was better than we anticipated.
We got much more than we expected out of the first race of the season;
we came here aiming to score points with all four cars.
This certainly bodes well for the championship.
"To do this at our home race in Aston Martin's centenary year is extra special.
I'd like to particularly thank the technicians and engineers and all others who have worked tirelessly since Shanghai to expand to this four-car effort.
We look forward, as a team, to challenging for more race wins."

The race-winning 2013-specification #97 Vantage GTE - which shares its bonded aluminium structure and basic engine and suspension architecture with Aston Martin's sportiest road-going model, the V8 Vantage - completed 171 laps of the 3.7-mile Silverstone circuit, equating to a total race distance of more than 630 miles at an average speed of 108mph.

The FIA World Endurance Championship resumes in Belgium next month at the Six Hours of Spa-Francorchamps with the race due to start at 1430hrs (CET) on Saturday, 4 May.

14 April : Silverstone, UK "Victory!"
4 May : Spa-Francorchamps, Belgium
22-23 June : Le Mans 24 Hours, France
1 Septembe : Interlagos, Brazil
22 September : Circuit of the Americas, USA<
20 October : Fuji, Japan
10 November : Shanghai, China
30 November : Bahrain

TITLE CHALLENGE BEGINS AT HOME FOR TURNER

2013-04-12T01:57:59Z

Darren Turner begins his world title challenge this weekend when Round One of the FIA World Endurance Championship takes place at Silverstone.
Although the title hunt starts at home for Turner it will take the Aston Martin Racing driver all over the world from Europe to South America, the USA, China and Japan, before finishing up in Bahrain just a few weeks before Christmas.

Darren's comment: " I've had new gloves made for this season. Super fast!"

After a busy pre-season which has seen the Aston Martin Racing team test extensively in the USA, Darren is keenly aware that the cool Spring in the UK could throw up a few challenges for the teams at Silverstone.

"The most interesting aspect for us at Silverstone will be the low temperatures and how we go about making the tyres work," explained Darren.
"Last year we were lucky that race day was slightly warmer than the previous days as this certainly helped us."
"It's great to start the championship at Silverstone as it's right on Aston Martin Racing's doorstep and considering the amount of work the guys are having to do to get four cars ready for this weekend it's handy that they're not having to travel too far from home."

The Aston Martin Vantage GTE debuted in 2012 and made steady progress throughout the FIA WEC season before Darren and his team-mate Stefan Mucke took a brilliant victory in Shanghai.
The challenge now is to keep the momentum going and stay on the winning streak as the 2013 season swings into action.
"The work the team has done over the winter has produced very encouraging results, especially in terms of performance and driveability," said Darren.
"As ever when you go into the new season you don't know what the performance level of the competition will be and there is no doubt Ferrari and Porsche haven't stood still over the winter.
The encouraging thing is that we haven't either and if we can start 2013 as we ended 2012 then we're already on for a great championship."

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"The car ran incredibly reliably throughout our time in the States" he continued.
"The real season starts now at Silverstone."

The WEC cars will take to the track at Silverstone for the first free practice session this Friday at 12:25hrs.
GT qualifying takes place on Saturday at 12:10hrs and the six-hour FIA World Endurance Championship race gets underway at 12:00hrs on Sunday.
The race will be broadcast live on Motors TV.

2013 FIA WORLD ENDURANCE CALENDAR

14 April: Silverstone, UK
4 May: Spa-Francorchamps, Belgium
22-23 June: Le Mans 24 Hours, France
1 September: Interlagos, Brazil
22 September: Circuit of the Americas, USA
20 October: Fuji, Japan
10 November: Shanghai, China
30 November: Bahrain

FPP and Osato Research Institute appeared in the Magazine called "ENGINE".

2013-02-05T05:56:39Z

The March issue of the magazine "ENGINE" published by Shinchosha Co., Ltd
on 26th of January featured the O.R.I. activities in its article.

The March issue of the Magazine "ENGINE", featuring FPP, sells for 880 yen at bookstores now.
I hope you might try it yourself.

Aston Martin GT4 Challenge of Great Britain Awards EveningImmun'Age OSATO V8 won 7 rounds out of 8 and became champion of the year 2012.

2013-01-22T06:10:10Z

James Bonders 008, 009, 010

On December 4th when Christmas is near, the GT4 Challenge of Great Britain Awards Evening was held at Aston Martin Head Quarters in Gaydon, England, where the green pastures are beautiful even in mid-winter.

Celebrating the victory around the Immun'Age Car
From left, Yuki, Dr. Bez CEO, Oliver, Richard Chairman, Dr. Pierre

The Immun' Âge OSATO V8 participated in the GT4 Challenge with Dr. Pierre Mantello of Osato Research Institute and Olivier Bouche as drivers. Although the total of their ages is 110 years old and they are not really young anymore, they won 7 rounds out of 8 and became champions of the year 2012. Maybe it is because they had a traction advantage due to their big bodies.

Congratulations, Pierre and Oliver! What a good Job!
The Aston Martin's CEO and the Chairman of Aston Martin Racing also gave their blessings.

The effect of Immun'Âge was proven even in the race field by these elder drivers.

Speech of Mr. Yuki Hayashi on behalf of Osato Research Institute

At the award party, the bond car DB5 which was used in the 007 movie "Sky Fall" released in November was also displayed and the Immun'Âge car was dazzling with the Japanese National flag on its roof. January 15, 2013 is 100th anniversary of Aston Martin and there will be numbers of events this year that we can't take eyes off.

What a great achievement for Japan!
Feeling so grateful for this victory


Aston's driver, Darren, also came to congratulate us.	Posing as if I were to be 007

Christmas tree and the Bond Car	Beautiful female driver attending the party

The Award Evening was held at the lobby of the Aston Martin's Headquarters. New Vanquish was also displayed.

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Radio-protective effect 【second report】

2013-01-08T10:53:59Z

We obtained interesting results from the experiments on Radio-protective effect of Fermented Papaya Preparation (FPP), and the following is the second report.

In this report we summarize results of a study regarding the effect of FPP on radiation-induced damage in cultured cells and in mice.

Irradiation was carried out in a Gammacell 220 (MDS Nordion, Excel, Canada).

【In vitro studies】
Human foreskin fibroblasts were seeded in 96-well plates, 2000 cells/well. After overnight incubation, the cells attached, and the plates were irradiated by at 4 doses: 0, 6, 12 and 18 Gy. After irradiation, FPP, at concentrations of 10, 50 or 100 µg/ml (sterilized through a 0.22 m filter), was added to each well, and the cells were incubated for 2 or 3 days. Cell survival was estimated by CellTiter 96 Aqueous Non-Radioactive Cell Proliferation assay for cell vitality.

Results are shown as mean±SD, N=5.

Additional experiments were carried out on human HL60 cells growing in suspension. The cells were irradiated at various doses and then treated with FPP. After 24 hr, phosphatidylserine exposure and propidium iodide staining (markers of apoptosis and cell survival) were measured.

Results are shown as mean±SD, N=5.

【In vivo studies】
Mice were irradiated at various doses (0, 6, 10 and 14 Gy). The mice were then fed with FPP (by adding it to the drinking water). After 3 days, the marrows from the femur bones were obtained and phosphatidylserine exposure and propidium iodide positive cells were measured.

Results are shown as mean±SD, N=5.

Mice were irradiated at various doses. The mice were then provided with FPP (in the drinking water), and observed daily for 3 weeks.

The results of one experiment (6 mice per group).

【Conclusions】

The results suggest a significant protective effect of FPP on irradiated cells and mice.

【Possible mechanisms of operation】

Radiation-induced damage is mediated in part by free radicals, particularly free oxygen radicals (reactive oxygen species, ROS) [1]. Toxic ROS may also be generated by "labile iron" ("free" cellular iron not bound or stored in proteins such as hemoglobin and ferritin). These iron species participate in chemical reactions that generate ROS (Haber-Weiss and Fenton reactions).
FPP has been shown to have anti-oxidative potential. Recently, we have found that this is not just because of its ability to bind and remove ROS (as a scavenger), but also because of its ability to bind and remove (from the blood and from cells) excess iron (as a chelator) [2].

【Future Plans】

Based on the present results, and in order to prepare the data for publication, we believe that the following additional research is worthwhile regarding the specific protective effect of FPP on the DNA and mutagenesis. These aspects are important because of the long-term carcinogenic effect of irradiation.

In vitro experiments

Irradiated cells treated with FPP will be studied for oxidation of the guanine nucleotide (8-OHdG) in the DNA (a marker of DNA damage) and generation of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutants.

In vivo experiments

Irradiated mice under FPP-supplemented diet will be studied for 8-OHdG in the DNA in their peripheral blood leukocytes, and GPI- (negative) phenotype (a marker of genetic instability and mutations) in their red blood cells.

【References】

Reizenstein P. Iron, free radicals and cancer. Med Oncol Tumor Pharmacother. 1991;8:229-233.
Prus E, Fibach E. The antioxidant effect of fermented papaya preparation involves iron chelation. J Biol Regul Homeost Agents. 2012;26:203-210.

Introduction of the existing paper

2012-11-09T01:27:07Z

"Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population" was placed in Preventive Medicine at 2012.

Introduce again

Clinical evidence and cellular models have shown an inverse relationship between the intakes of plant and fruit based diets and oxidative stress, suggesting the suitability of natural antioxidants in the management of diabetes mellitus and its complications. A randomized controlled clinical trial was conducted at the Cardiac Centre, SSRN Hospital, Pamplemousses, (Mauritius) to determine the effect of a short term supplementation of a fermented papaya preparation (FPP®) on biomarkers of diabetes and antioxidant status in a multi-ethnical neo-diabetic population from November 2010 to March 2011. Supplementation of 6 g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes. When comparing experimental to control groups with independent samples t-test, C-reactive protein levels significantly decreased (P=0.018), LDL/HDL ratio was considerably changed (P=0.042), and uric acid levels were significantly improved (P=0.001). ANOVA results also validated the same findings with significant differences in C-reactive protein, LDL/HDL ratio, uric acid and in serum ferritin levels. FPP® may present a novel, economically feasible nutraceutical supplement for themanagement of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress.

【Table1】Effect of a fermented papaya preparation on a neo-diabetic Mauritian population under the FPP® and control regimens (N=41) during the intervention period November 2010 to March 2011 Significance testing as Independent samples T-test amongst the pre and post supplementation groups when comparing experimental and control groups .

Please click the title to read the whole paper.

Goodwood Revival

2012-11-08T09:54:36Z

I had a phone call from Aston Martin Works Director Kingley at the prestige brand's spiritual home in Newport Pagnell.
He asked me if they can display my bond car DB5 at the Goodwood Revival as a work of Aston Martin, which has been fully restored in commemoration of their 100th anniversary since 2010, with a kind invitation to join the event. In mid-September, I and my wife headed for the Goodwood Circuit, 30 minutes by car from Portsmouth.

Goodwood circuit entrance

The Goodwood Circuit is owned by Lord Charles March and was provided as an air force base by his farther. There were many races held in the 50's and 60's, but in 1966, Goodwood closed its gates to contemporary motor racing. However, the circuit, including all the pits and the stands, remained as it was, thanks to his great wealth. In 1998, Lord Charles March created Goodwood Revival as the greatest classic car race in the world to make his dream come true.

15 out of the existing 39 Ferrari 250 GTO participated in this race.
Real flight of the cars which value over 10 billion yen in total.

The event was held from Friday to Sunday and the dress code was fashion in the 50's and 60's. Not only a total of 140 thousand visitors but also the police station, the fire station, restaurants and shops including their staff, and cars were like stepping back in time.

It's not cosplay (costume play) ! All of them are so fashionable.

Vintage Aircrafts such as Mustang Spitfire added grace to the event, flying from the airport located in the middle of the circuit.As I saw many elderly couples, almost 70 years old, walking hand in hand with each other and looking happy in the vintage fashion of their younger days, I felt envious.

I thought we should have this kind of event in Japan where the population is aging.


Staff of Aston Martin Newport Pagnell being dressed in an old fashion as you can see	With CEO of Leica

Car in the 20's !	Real police officers also dressed up.

A little bit nervous with beautiful ladies in front of my wife...	My DB5, made in 1964, also looks happy being back in time.

The engine being finished so beautifully	Waitress classically dressed!/td>

Nice couple	What a fashionable lady!

In front of Mustang	The bags sold in the shop are also classical

What a crowd! So many people in UK All fashionably dressed up

Functional foods in genomic medicine: a review of fermented papaya preparation research progress

2012-10-24T01:16:00Z

New papers have been published.

FPP has function to engage genes such as GSTM1, Hsp70, leucocyte GPx, SOD, catalase and hOGG1.　

Abstract

"Functional Foods" represent an emerging opportunity and they will certainly play a consistent and important role in future too. Such a new perspective entirely depends on the growing attention paid by nutritionists to the development of new innovating solutions aiming at acting on organic systems as well as on more general topics relating to consumer good health conditions. Differently from the past, when mainly retrospective epidemiological studies or empirical experiences were carried out on single nutrients, such a new and growing interest by the scientific community follows research deeply oriented to clinics supplemented by an accurate study on nutrients, genomics and single nutritional requirement diagnostics. Already in 1993, the leading journal Nature published a report "Japan is exploring limits between food and medicine" (Swinbanks 1993). Clearly the success of "Functional Foods" depends on the food industry capacity too of developing new effective products which on the one side meet any consumer request and on the other must be have positive effects on health, supported and validated by scientific research and therefore far beyond simple positive properties, as recently underlined in a meeting, organised by a no profit non governmental international association. (www.actabiomedica.it)

Please click the title to read the whole paper.

Inauguration ceremony of the new Curie Museum

2012-10-11T09:48:55Z

Summer is over, and in autumnal sunshine the opening ceremony of the renovated Curie Museum was held in Paris on September 13, 2012. It is located in the Curie Institute in the Latin Quartier of the 5th arrondissement of Paris, which is in the hospital of the Pierre-and Marie University, known as "Paris VI", covering radiotherapy researches for cancer treatments. The laboratory of Marie Curie is reserved as it was when she was alive and it has been open to public as a part of the museum. She is famous for her pioneering research on radioactivity including the discovery of two elements, polonium and radium. She is the one who laid the groundwork for the current radiotherapy.
Madame Curie won the Nobel Prize twice, first in physics in 1903 (the award was shared with her husband, Pierre Curie, and Henri Becquerel) and again in chemistry in 1911. She became the first female professor at the University of Paris and opened the door for female scientists more than 100 years ago. She was a wonderful mother as well. She was married to Pierre and had two daughters, Irène and Ève. She was good at housework such as cooking and needlework. She was like a modern ideal female in the sense of balancing her career and child-raising with the help of her father in law.
Her elder daughter Irène supported her research with her husband and they were jointly awarded the Nobel Prize in Chemistry in 1935 for their discovery of artificial radioactivity, which was the 5th Nobel Prize in the Curie Family. Her younger daughter Ève learned Piano, not Physics or Science and took good care of her mother in her private life. She nursed her mother with devotion until her death. Her husband Labouisse was the executive director of UNICEF and collected the Noble Prize for peace in 1965 on behalf of UNICEF. The life of Ève seemed to be most closely connected to Nobel Prize laureates.

The renovation of the museum was made by the legacy of Ève Curie according to her will, who died in her sleep on 22 October 2007, aged 102. It is said that she felt enormous guilt that she alone among the women in her family had escaped a life of radiation and its consequences of living long. She must have wanted to show more people the achievement of her parents and her elder sister and her husband by this renovation of the museum.
The Osato Research Institute have been dedicated to support a project of preserving historical resources about Madame Curie and her two daughters' visit to USA during the year of 1921 in order to show them visitors of the Curie Museum in Paris.
The Osato Research Institute also helped the large screen display to get installed in the center of the museum under the large photo panel of Mr. and Mrs. Curie, her daughter Irène and her husband Frédéric Joliot-Curie so that visitors can see many photos and get information on the achievement of Madame Marie Curie and her family members, including the five Nobel Prizes awarded to them, by use of a touch panel screen like iPad. Mr. Hayashi, president of the Osato Research Insitute, and his wife were invited to the ceremony held on September 13, 2012 to celebrate the renovation of the museum and got honored to receive special thanks by Prof. Claude Huriet, director of the Curie Institute, and two grandchildren of Madame Curie, Hélène Langevin-Joliot (female nuclear physicist) and Pierre Joliot (biophysicist) who attended the ceremony.

Welcoming large photo panel of Mr. and Mrs. Curie, her daughter Irène and her husband

Mr. and Mrs. Hayashi with grandchildren of Mrs. Curie, Hélène (female nuclear physicist) and Pierre (biophysicist)

Memorable photograph with family of Pierre
Feeling the weight of the history of science and wonder through an encounter with people

With Prof. Claude HURIET, director of the Curie Museum, and Hélène All looking happy with the new Curie Museum

Capturing the moment of Mrs. Curie standing in front of her own aboratory
Feeling as if she was sending a message to us that science exists for people.


Ribbon-cutting by the Grandchild of Madame Curie, Hélène, and the director of the Curie Institute	Just after finishing the ribbon-cutting

Grandchild of Madame Curie, Hélène	Looking so happy

Aperitif at the celebration gala	Aperitif at the celebration gala

With Prof. Louvard, Research Director of the Curie Institute, in front of the Curie Museum which used to be the Radium Institute of which Madame Curie was the director	Entrance of Curie Museum

With the architect	Precious document on US visit of Madame Curie and her daughters

Desk used by Madame Curie	Portrait of Madame Curie

Access Map

More Information about Curie Museum

Flash report

2012-10-05T09:15:44Z

Flash report

The 6 hours Fuji, the 7th round of the 2012 season of the FIA World Endurance Championship, will be held from 12th to 14th of October 2012.

On 26th of August, the #97 Aston Martin Vantage GTE has finished third in the GTE Pro category in its home FIA World Endurance Championship race, the Six Hours of Silverston.

On 15th of September, Aston Martin Racing has finished second in the GTE Pro class in the fifth round of the FIA World Endurance Championship (WEC), the Six Hours of Sao Paulo, achieving its best WEC result to-date.

Then, on 29th of September, Aston Martin Racing has finished the sixth round of the FIA World Endurance Championship (WEC), the Six Hours of Bahrain, in second place - very close to the first place.↑Click here to see the race report.↑

The performance is getting better and better and so is the condition of their machine.
We are so looking forward to seeing their best performance in 6 hours of FUJI on 14th of October!!

Their excellent performance against the well-known cars such as Ferrari F458 Italia and Porsche911 RSR will be expected.

Why is it recommended to place FPP in mouth and let it dissolve with saliva?

2012-09-20T07:45:37Z

Why is it recommended to place FPP in mouth and let it dissolve with saliva?

It is because the following effects are expected:

Prevention of upper respiratory tract infection and improvement of immunity

Improvement of enteral environment with maltooligosaccharide, and intestinal immunity regulation

Stimulation of the antioxidant systems recognized by Health Canada

The detailed explanation is stated as below:

In the clinical trial on FPP to see the effect in common seasonal respiratory tract infection conducted by Prof. Francesco Marotta (University of Milan, Italy) in 2010, FPP supplementation resulted in improvement of immunity, increase of salivary secretion, upregulation of redox gene expression from upper airway cells. Specifically, with FPP supplementation of 9g per a day during 6 weeks, salivary secretion was significantly increased, nearly double in the young age group, and the production level of IgA (biomarker of immunity) and lysozyme (enzyme with bacteriolytic effect) were increased in saliva, and SOD (Superoxide dismutase : enzyme with a key antioxidant role) and phase II enzyme gene expression were upregulated. It suggests that it will hopefully help reducing the incidence and/or severity of upper respiratory tract infection.

Journal of Biological Regulators & Homeostatic Agents Vol. 26, No. 2(2012).
Please click here to read the full-text paper.

Also, a basic research of the saccharides in FPP conducted by Keiko Nishida, a researcher of Osato Research Institute, showed that some contents of saccharides in FPP increased significantly when they were mixed with saliva in mouth. Specifically, maltose and maltotriose increased respectively 2.4 times and 13.1 times. Maltose and maltotriose are a kind of maltooligosaccharides, which is considered to improve enteral environment and be closely associated with immunity. Therefore, it suggests that mixing FPP with saliva in mouth will help to improve enteral environment and regulate immunity.

This research was presented in the annual meeting of the
Japanese Society of Applied Glycoscience in 2010.
Please click here to read the summary in Journal of Applied Glycoscience.

Since April 2011, FPP has been officially recognized as Natural Health Product (NHP) by Health Canada and been authorized to make the health claim of "Stimulates the antioxidants systems for the maintenance of good health". NHP is a category for the products between foods and drugs. In order to be recognized as NHP, manufacturers must submit application to Health Canada including information about uses, formulation, dosing, safety and efficacy together with international clinical papers as evidence. Because of the numerous clinical trials and scientific papers on FPP, its property to stimulate the antioxidant systems has been recognized by Health Canada.

The above article is quoted from the Website of OSATO International, Inc. - external website -

We can see from the above that the effects of placing FPP in mouth and letting it dissolve with saliva are:

Prevention of upper respiratory tract infection and improvement of immunity

Improvement of enteral environment with maltooligosaccharide, and intestinal immunity regulation

Stimulation of the antioxidant systems recognized by Health Canada

We can expect such beneficial effects of prevention of disease and maintenance of good health.

You can take 3 sachets of FPP (3g x 3) dissolving in half a cup of water,
in case you are confined to bed and do not have enough salivary secretion.

New papers have been published.

2012-09-14T04:41:39Z

5 papers have been already published so far in 2012.
The fourth and fifth papers are shown below.

Please click the title to read the whole paper.

CARDIO-PROTECTIVE EFFECT OF A BIOFERMENTED NUTRACEUTICAL ON ENDOTHELIAL FUNCTION IN HEALTHY MIDDLE-AGE SUBJECTS

Rejuvenation Res. 2012 Apr;15(2):178-81.

The Antioxidant effect of Fermented Papaya Preparation
Involves Iron Chelation

J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):203-10.

Radio-protective effect

2012-09-12T07:02:55Z

We obtained interesting results from the experiments on
Radio-protective effect of Fermented Papaya Preparation
(FPP), and the following is a special preview.

The experiments suggest a significant protective effect of FPP on cell survival/proliferation of human foreskin fibroblasts when added immediately after different doses of irradiation (Fig.).

Human foreskin fibroblasts were seeded in well plates, and after overnight incubation, the cells attached, and the plates were irradiated by a Gammacell® 220 (MDS Nordion,Excel, Canada) at 4 doses: 0, 6, 12 and 18 Gy. After irradiation, FPP, at concentrations of 10, 50 or 100 µg/ml, was added to each well, and the cells were incubated for 2 or 3 days. Cell survival was estimated by CellTiter 96® Aqueous Non-Radioactive Cell Proliferation assay for cell vitality. As shown in (Fig.), it showed a sharp decline in the cell vitality with the radiation dose, but FPP could reduce the loss of cell vitality in accordance with the concentrations.

It suggests that FPP can repair cellular damage after irradiation.

Additional experiments in vivo and/or in vitro are planned in order to investigate the specific mechanism(s) by which FPP protects the cells from irradiation damage, and in addition to survival / proliferation, cells will be assayed for apoptosis, DNA changes and mutations.

DNA damage and mutagenesis are important because indicate the carcinogenic effect of irradiation.

OSATO Immun'Âge, 4 Victories in 5 races!!! ~They already win the challenge!?~

2012-08-07T04:52:25Z

13 - 14 JULY - BRANDS HATCH (GP CIRCUIT) Winner
29 JULY - DONINGTON PARK (NATIONAL CIRCUIT) Winner

In the Aston Martin GT4 CHALLENGE at DONINGTON PARK on 29 July 2012,

OSATO Immun'Age of Dr.Pierre Mantello (Director of Osato Research Institute) and
Olivier won the race starting from the last position on the grid due to the mechanical trouble
in the qualification.

The moment the car crossed the finish line, Pierre showed his joy of victory giving the piece sign!

Also, at the BRANDS HATCH on 14 July 2012, they crossed the finish line in the first place.

However, they ended up in the second place being penalized for the slip during the race,
which made them lose a victory for the first time this year.

28 APRIL - SILVERSTONE (NATIONAL CIRCUIT) Winner
12 MAY - OULTON PARK (INTERNATIONAL CIRCUIT) Winner
4 - 5 JUNE - BRANDS HATCH (INDY CIRCUIT) Winner
13 - 14 JULY - BRANDS HATCH (GP CIRCUIT) Winner
29 JULY - DONINGTON PARK (NATIONAL CIRCUIT) Second Place

14 - 15 SEPTEMBER - SPA FRANCORCHAMPS
29 SEPTEMBER - SNETTERTON (300 CIRCUIT)

Le Mans 24 Hours racing(2012)

2012-07-09T10:13:45Z

Aston Martin takes part in several 24-hour races to demonstrate their high performance and durability as GT car.

The season for the 24-hour races has arrived as they finish the severe cold winter and head into the spring in Europe.

The second race was the 24 Hours of Le Mans held on 16th and 17th of June.

The circuit is 13.629 km long with 38 curves and consists of both permanent track and public roads.

It is famous as a high-speed circuit where the cars could travel at more than 300 km/hour.

The ACO allowed 55 cars selected from all over the world including hybrid vehicle for the first time to be entered in this 80th memorial 24 Hours of Le Mans.

It was also Le Mans that accepted diesel racing cars for the first time.

Aston Martin entered a Vantage V8 into the GTE Pro category.

Ferrari entered even 4 cars into this category, and Corvette and Porch also entered.

In the beginning of the race, Aston and Corvette were involved in an exciting battle for the lead, which reminded me of 2005 Le Mans.

Aston Martin completed the race of 4,500 km and ended up in 3rd position following two Ferrari cars.

I would like to applaud form the bottom of my heart staff and drivers of Aston Martin for their excellent work under such severe conditions which had no tolerance for mistakes for 24 hours.

On the day before the race, I was invited to the golf event "GOLF DES 24 HEURES" hosted by ACO and Rolex.

It was a tournament of three-member teams with one professional in each team.

I participated as a member of Immun'Age team.

The golf course was right next to the Mulsanne corner of the circuit and it was a very beautiful course well separated by pine tree forest.

It was a luxurious moment to play golf to the sound of participating cars in Le Mans.


We played as OSATO Immun' Age Team for Aston Martin Racing. How did the result turn out?	Because the course was right next to the Le Mans circuit, I was worried about the chance of hitting cars with a golf ball.

Both professional and amateur pared the first hole. Where is the next hole?	Being relaxed at the club house in front of the podium

At the Aston Martin Festival held before the 24-hour race Who is the man next to me?	OSATO Immun' Age car also ran at Le Mans with Dr. Pierre.

Who is this Michelin Man? He is a director of Osato Research Institute. In front of the Hospitality	In front of the Hospitality of this year's Le Mans

Quiet moment before the race	At the ceremony just before the race

Mr. and Mrs. Richards looked relaxed this year since the car was running well.	Beautiful sun set at Le Mans At 10:00 pm, 7 hours after the race started

The best way to check the race is watching TV.	Display of T shirts with Immun'Age logo

It was fun planning for their 100th anniversary year of 2013 with CEO Dr. Bez	One hour before the end of the race Waiting together with Driver Darren and David King

Hurry for the commendation ceremony of the 24 Hours of Le Mans	We were so proud of their podium. Great achievement!

The commendation ceremony was full of members of each team. What a crowd of people!	Mr. John Gaw, Managing Director Aston Martin Racing, also looks happy.


With drivers who finished on the podium at the 24 Hours of Le Mans! Darren also looks happy.